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2) cannot be explained by a simple increase of seismic velocity with depth Consequently, either the chemical composition must be more ma c, or denser, high-pressure phases are present Information derived from geologic studies supports this conclusion, indicating that continental crust becomes denser and more ma c with depth In addition, the results from these studies show that the concentration of heat-producing elements decreases rapidly from the surface downwards This decrease is due, in part, to an increase in metamorphic grade but is also due to increasing proportions of ma c lithologies In areas of thin continental crust, such as in rifts and at rifted margins, the middle and lower crust may be composed of low- and moderate-grade metamorphic rocks In regions of very thick crust, such as orogenic belts, the middle and lower crust typically are composed of high-grade metamorphic mineral assemblages.

review another arm s approvals; an independent safety review board might be needed to avoid the inherent conflict of interest that arises when an agency analyzes its own past decisions There will always be denial, rejection, and heat when safety questions are raised about approved drugs, charged David Graham, the staffer who raised such questions about Vioxx and who claimed higher-ups at the FDA tried to intimidate him At the least, all the publicity would keep everyone on their toes for a while Actually, a lot of the post-market data the FDA needs exists already The problem is that it is buried in the clinical trials that pharmaceutical manufacturers pay for and design but never publish.

an integrated scheme for managing a project The idea here is that in planning, a network plan is developed as traditionally, but the project manager uses the SD project model to test the likely outcome of that plan (having rst calibrated the SD model by the network) Similarly, in monitoring, metrics are collected, and the SD model is calibrated to reproduce past behaviour This thus represents a robust project model with which to experiment and plan The SD models are linked to the project network models with formal data- and structure-links, including a more general hierarchical version of the ideas in the section above on using conventional tools to generate SD models Figure 106 illustrates the bare essentials of this scheme, although a great deal more richness is described in Rodrigues (2001) and Rodrigues and Williams (1997, 1998).

These are the most systematic, scientific tabulations of all of a drug s effects, bad and good, and they often are done after the drug is on the market, as well as during the approval process If a trial shows that a drug works, the company that makes the drug will probably submit the results to medical journals, give copies to sales reps to tote around to doctors, and issue an enthusiastic press release If a trial does not show any benefit, however, it usually disappears from the face of the earth The topic burst into public view in the spring of 2004 just as the FDA was issuing its stricter warnings for antidepressants Everyone knew that there were no studies clearly indicating whether the drugs worked on teens or, conversely, whether the drugs increased the risk of suicide among teens.

The middle crust in general may contain more evolved and less ma c compositions compared to the lower crust Metasedimentary rocks may be present in both layers If the lower crust is dry, its composition could correspond to a high-pressure form of granulite ranging in composition from granodiorite to diorite (Christensen & Fountain, 1975; Smithson & Brown, 1977), and containing abundant plagioclase and pyroxene minerals In the overthickened roots of orogens, parts of the lower crust may record the transition to the eclogite facies, where plagioclase is unstable and ma c rocks transform into very dense, garnet-, pyroxene-bearing assemblages (Section 99) If the lower crust is wet, basaltic rocks would occur in the form of amphibolite If mixed with more silicic material, this would have a seismic velocity in the correct range.

Then it was revealed that GlaxoSmithKline actually did have some trial data on its drug Paxil that it had never made public And the FDA had had that information all along Suddenly, the FDA was caught in the middle Companies submit reams of data to the agency, but by law the regulators must keep a lot of that secret For instance, the FDA gets all results from clinical trials that are conducted as part of a new drug or biologic application That information stays confidential unless the drug is approved, at which point only summaries are made public, under the theory that disclosing too many details could reveal trade secrets about how the drug was made As for trials that are conducted after a drug is in use typically, to get a supplemental application only the safety data must be reported promptly to the FDA.